Fig. 6

TF supports tumor growth and IVC clots. 1 × 10⁶ AsPC-1 (TF^high/TF^KO) and MIA PaCa-2 (TF^high/TF^low) cells were orthotopically injected into the pancreas of NSG and NSG-HA mice. After 5 weeks, IVC flow was completely blocked for 1 h, and the mice were sacrificed to measure (A, B) tumor weight and (C, D) clot weight. * Each dot represents one mouse, with n = 6–32 per group. Lines in dot plots represent the mean. p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001; **** p ≤ 0.0001; NS, non-significant